Preliminary work is scheduled to start Friday at a Lockheed Martin facility north of Atlanta.
The company said employment on the project will begin with a startup crew of 10 people and peak at roughly 600 when full-time production is under way in 2016.
The F-35 will be mostly assembled at a Lockheed Martin plant in Texas. But work on the wing will be conducted in Marietta.
Denise Rakestrow, president of a machinists' union, said the announcement is welcome news for her workers. Employees now working on the F-22 at the plant will transition to the new production line.