Investigators say one man acted as a lookout, while the other forced a female employee to open the cash register at gunpoint.
The men fled the Roswell Road drug store on foot with an undisclosed amount of cash, according to Sgt. Dana Pierce with Cobb Police.
The lookout is described as a six-foot-tall black man with a thin build, last seen wearing dark clothing.
Police say the gunman is a black man between six feet and six feet, two inches tall, who was last seen wearing a camouflage hoodie, dark pants and a red mask.
Anyone with information is asked to call (770) 499-3945, or by contacting Greater Atlanta Crime Stoppers at (404) 577-TIPS.