Scientists create wiring diagram for mouse brain
by Malcolm Ritter, AP Science Writer
April 02, 2014 01:15 PM | 361 views | 0 0 comments | 4 4 recommendations | email to a friend | print
This image provided by the Allen Institute for Brain Science on March 28, 2014 shows a top-down view of connections originating from different cortical areas of the mouse brain. The research published Wednesday, April 2, 2014 is the first brain-wide wiring diagram for a mammal at such a level of detail. While it does not reveal every connection between each of the rodent's 75 million brain cells, it shows how parts of the brain are connected. (AP Photo/Allen Institute for Brain Science)
This image provided by the Allen Institute for Brain Science on March 28, 2014 shows a top-down view of connections originating from different cortical areas of the mouse brain. The research published Wednesday, April 2, 2014 is the first brain-wide wiring diagram for a mammal at such a level of detail. While it does not reveal every connection between each of the rodent's 75 million brain cells, it shows how parts of the brain are connected. (AP Photo/Allen Institute for Brain Science)
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This image provided by the Allen Institute for Brain Science on March 28, 2014 shows connections between four distinct visual areas in the mouse cortex, in green, yellow, red, orange. These cortical areas are highly interconnected with each other and with additional areas involved in vision in the thalamus, pink, and midbrain, purple. The research published Wednesday, April 2, 2014 is the first brain-wide wiring diagram for a mammal at such a level of detail. While it does not reveal every connection between each of the rodent's 75 million brain cells, it shows how parts of the brain are connected. (AP Photo/Allen Institute for Brain Science)
This image provided by the Allen Institute for Brain Science on March 28, 2014 shows connections between four distinct visual areas in the mouse cortex, in green, yellow, red, orange. These cortical areas are highly interconnected with each other and with additional areas involved in vision in the thalamus, pink, and midbrain, purple. The research published Wednesday, April 2, 2014 is the first brain-wide wiring diagram for a mammal at such a level of detail. While it does not reveal every connection between each of the rodent's 75 million brain cells, it shows how parts of the brain are connected. (AP Photo/Allen Institute for Brain Science)
slideshow
This image provided by the Allen Institute for Brain Science on March 28, 2014 shows a circular wiring diagram of connections among 215 distinct regions throughout the mouse brain. Connections originating from 11 cortical regions are highlighted in different shades of colors, with the rest shown in gray. The research published Wednesday, April 2, 2014 is the first brain-wide wiring diagram for a mammal at such a level of detail. While it does not reveal every connection between each of the rodent's 75 million brain cells, it shows how parts of the brain are connected. (AP Photo/Allen Institute for Brain Science)
This image provided by the Allen Institute for Brain Science on March 28, 2014 shows a circular wiring diagram of connections among 215 distinct regions throughout the mouse brain. Connections originating from 11 cortical regions are highlighted in different shades of colors, with the rest shown in gray. The research published Wednesday, April 2, 2014 is the first brain-wide wiring diagram for a mammal at such a level of detail. While it does not reveal every connection between each of the rodent's 75 million brain cells, it shows how parts of the brain are connected. (AP Photo/Allen Institute for Brain Science)
slideshow
NEW YORK (AP) — Scientists have created a detailed, three-dimensional wiring diagram of the mouse brain. That should help researchers seek clues about how the human brain works in health and disease.

It's the first brain-wide wiring diagram for a mammal at such a level of detail. While it doesn't reveal every connection between each of the rodent's 75 million brain cells, it shows how parts of the brain are connected.

The work was described online Wednesday in the journal Nature by Hongkui Zeng and colleagues at the Allen Institute for Brain Science in Seattle.

To create the diagram, scientists combined data from more than 1,000 mouse brains, each of which was divided into 140 slices.

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Online: Nature: http://www.nature.com/nature 

Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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