Following a foul with 0.4 seconds to play, the Greyhounds missed a pair of free throws that could have tied or won the game.
Pope led 20-13 after one quarter and Osborne did not come back to take the lead until the 5 minute mark of the fourth.
D’Haire Henry led the Cardinals with 25 points, Kyrie Hogan had 17 and Delone Murphy finished with eight points and eight rebounds.
Osborne travels to Sprayberry on Jan. 22.
Sprayberry 81, Riverwood 41: The Yellow Jackets’ unbeaten run through Region 7AAAAA continued with the road rout in Sandy Springs.
Up six after the first quarter, Sprayberry (14-4, 8-0) extended its advantage to 41-20 by halftime and 56-27 by the end of the third.
Armel Potter finished with 32 points, eight rebounds and six assists. Wayne Jackson added 14 points, while Nkem Ojeh had 12 points, 11 rebounds and five blocks.
Sprayberry will host Cambridge on Thursday, playing a day early with the county wrestling tournament taking place at its gym Friday.
Allatoona 91, East Paulding 43: The Buccaneers had five players in double figures as they rolled to a Region 5AAAAA victory.
Allatoona (17-0, 10-0) led 32-11 after the first quarter and 57-21 at the half.
Rodney Brown scored 14 points, Ephraim Tshimanga and Drew Swanson each had 12, Daniel Fowler finished with 11 and Malik Cornelius added 10.
The Buccaneers travel to Hiram on Saturday.
Hillgrove 77, Harrison 58: The Hawks turned a two-point deficit after one quarter into an eight-point lead by halftime and cruised from there.
Kyle Castlin led Hillgrove (14-3, 8-2) with 24 points, while B.J. Brown had 20 and Keith Ray 16.
Justice Morgan had 17 points to lead Harrison (7-12, 3-7), which was backed by Jack Forrest’s 15 and and Nick Hughes’ 10.
Hillgrove will travel to North Cobb on Friday, while Harrison is at Campbell.
Kennesaw Mountain 56, Kell 50: The Mustangs mounted a rally in the fourth quarter, coming back to beat their county rival.
Nigel Hayes had 16 points for Kennesaw Mountain (6-10), with Andrew Jimenez adding 16. Khaleed Case and Josh Craig each had eight for the Mustangs, who will travel to Marietta on Friday.
Grant Bryant’s 17 points led Kell (6-12), which will go to Northview on Friday.
Roswell 58, Lassiter 44: The Trojans had the Hornets within four points at halftime, but that was as close as they could bring the Region 5AAAAAA game.
Derrick Lloyd had 17 points for Lassiter (3-13, 0-6), which will travel to Wheeler on Friday.
St. Francis 60, North Cobb Christian 59: A furious fourth-quarter rally came up just short as the Eagles dropped a key Region 6A (B) contest.
Kendall Crute connected on three 3-pointers and scored 11 of his 18 points in the final period to bring North Cobb Christian back from a 14-point deficit. The Eagles had a chance to win in the final seconds, but a shot at the buzzer bounced off the rim.
North Cobb Christian (13-4, 6-1) started the game by missing its first 14 shots.
Hunter Ware scored 15 points, Stephon Jelks had 12 points with 12 rebounds, and Trey Kalina finished with eight points, 13 rebounds and three blocks.
The Eagles host Mount Paran Christian on Friday.
Dominion Christian 58, Weber 46: After Weber made a push for the lead in the third quarter, Dominion was able to regain its edge in the fourth.
Jordan Dorsey finished with 26 points and seven rebounds, while Tate Cooney had 12 points and seven rebounds.
Dominion (6-7, 1-1 GISA Region 1AAA) will host the Heritage School on Friday.
Shiloh Hills Christian 68, Mountain Area Christian 41: The Challengers dominated the GCAA North game, taking a 36-point lead into the fourth quarter.
Austin Greenway finished with 18 points and five steals, while Jon Allen added 17 points, eight rebounds and five assists. Trey Bleck had 13 points for Shiloh Hills (15-4, 6-0), which will travel to King’s Way Christian on Thursday.
Whitefield Academy 73, Walker 40: Eric Lockett totaled 19 points, seven rebounds and four assists to lead Whitefield Academy to the Region 6A road win.
Lawrence Waters chipped in a double-double with 11 points and 13 rebounds, while Courtney Alexander added 10 points, 10 rebounds, an assist and two blocks.
Robert Baker scored 21 points for Walker and pulled down 10 rebounds, Zach Hamilton had six points and four assists. Ahmad McCullough had six points and six assists.
Whitefield hosts Fellowship Christian while Walker travels to Mount Pisgah Christian on Friday.
Hillgrove 51, Harrison 41: Mackenzie Engram scored nine of her game-high 22 points in the third quarter as the Lady Hawks pulled away for a Region 4AAAAAA victory.
Hillgrove (16-2, 8-1) led 23-22 at the half, but Engram, who also had 16 rebounds, paced a 19-8 run to break the game open.
Jaya Smith finished with six points and 10 rebounds and Zarriah Pierce added nine points.
Sidnee Wiggins led Harrison with 14 points and Kayla Wright finished with eight.
The Lady Hawks will travel to North Cobb on Friday.
North Cobb 60, Pebblebrook 40: Ty Broadwater’s double-double of 19 points and 11 rebounds led the Lady Warriors to the Region 4AAAAAA win.
Kyrie’ Chandler added 13 points, while Aniyah Corley and Chauntel Strahorn each had nine. Corley also had six assists.
North Cobb (12-5, 5-5) will host Hillgrove on Friday.
Brandi Brown’s 15 points and Precious Walker’s eight led Pebblebrook (2-13, 1-7), which will travel to South Cobb on Friday.
Campbell 57, South Cobb 26: The Lady Spartans never let up in their defensive pressure, forcing 40 turnovers and stealing the ball 24 times.
Julie McKie finished with 14 points and 11 rebounds, while Mikayla Lee had 11 points and four steals. Sherdia Francis had seven points, while Simone Spencer bolstered the defense with a team-high six steals.
Alex Brown had nine points for South Cobb (2-12, 0-8), which will be at Pebblebrook on Friday.
Campbell (13-4, 6-3) will host Harrison on Friday.
Kennesaw Mountain 44, Kell 43: Jaylah Carr went 5-for-6 from the free-throw line in the fourth quarter, helping the Lady Mustangs win the non-region game.
Carr finished with 15 points in all, while Sara Zimmerman had 10, with the help of three 3-pointers. Anna Stewart scored eight for Kennesaw Mountain (6-9), which will travel to Marietta on Friday.
Onyx Henderson had 15 points, with Santavia Grant adding 14 for Kell, which will travel to Northview on Friday.
Osborne 80, Pope 54: Zutorya Cook scored 29 points to lead the Lady Cardinals to a Region 7AAAAA (B) victory.
Osborne (12-5, 7-0) broke the game open early thanks to a pressure defense that finished with 24 steals for the game.
Cook added a team-high nine steals and six assists in the win. Alexis Singletary finished with 14 points and 13 rebounds, Nikira Goings had nine points, nine rebounds and six assists and Raven Brown added seven points and 11 boards.
The Lady Cardinals will travel to Brooklyn, N.Y. to compete in this weekend’s Rose Classic.
Mount Paran Christian 51, Mount Pisgah Christian 37: Renee Van Horn scored all 14 of her points in the second half to lift the Lady Eagles to a come-from-behind Region 6A victory.
Mount Pisgah jumped to a 9-0 lead and led 21-18 at the half, but Mount Paran tied the game at the end of three quarters and closed on a 19-5 run for the win.
Que Morrison led the Lady Eagles (11-3, 5-1) with 14 points and 10 rebounds, and Emily Spillane added 10 points.
Mount Paran travels to North Cobb Christian on Friday.
Walker 41, Whitefield Academy 39: Haley Timbrook only had four points in the Region 6A game, but two proved particularly key.
Fed the ball by Victoria Hudson, who took the inbounds pass from Honor Stoner, Timbrook hit a jumper from just inside the arc that beat the buzzer and gave her team the victory.
Walker (6-8, 2-3) won despite squandering the nine-point lead it took into the fourth. Whitefield (4-6, 0-6) was 9-for-10 from the free-throw line in the final period, while Walker did not have an attempt at the line.
Collier Middleton had a double-double of 25 points and 14 rebounds, while Timbrook had five assists for the Lady Wolverines, who will travel to Mount Pisgah Christian on Friday.
Grace Miller had 15 points, and Camryn Casey eight for Whitefield, which will host Fellowship Christian on Friday.
Shiloh Hills Christian 36, Mountain Area Christian 34: The Lady Challengers rallied for the GCAA North win, giving Mountain Area its first loss of the season.
Shiloh Hills (11-6, 2-3) trailed 28-21 entering the fourth quarter.
Samantha Henderson had a team-high 18 points, including 10 in the fourth, and added eight rebounds and six steals.
Shiloh Hils will travel Thursday to King’s Way Christian.