Santana received the Beacon of Change Award before the Braves-Phillies game.
The Grammy-winning musician said he was representing immigrants before adding: "The people of Arizona, and the people of Atlanta, Georgia, you should be ashamed of yourselves."
Georgia Gov. Nathan Deal on Friday signed a bill that cracks down on illegal immigration in the state. The bill requires many employers to check the immigration status of new hires and authorizes law enforcement officers to check the immigration status of some suspects.
Georgia's new law shares some similarities to one enacted last year in Arizona.
"This law is not correct. It's a cruel law, actually," Santana said in an impromptu news conference after the ceremony. "This is about fear. Stop shucking and jiving. People are afraid we're going to steal your job. No we aren't. You're not going to change sheets and clean toilets."
Added Santana: "This is the United States. This is the land of the free. If people want the immigration laws to keep passing, then everybody should get out and leave the American Indians here."