It will be the ninth trip to the elite eight, and the sixth in the last seven years, for Campbell (25-6), which will play Region 4AAAAA rival North Cobb in a 4 p.m. game at Fort Valley State University southwest of Macon.
"It's always great to (make it to the state quarterfinals)," Campbell coach Randy McClure. "This is something that we don't take for granted."
Campbell's win guaranteed that the two quarterfinal games at Fort Valley will be an all-Cobb - and all-Region 4AAAAA - affair. Hillgrove and McEachern will play at 7 p.m.
As usual, defense was the key factor for Campbell, which forced Valdosta into 37 turnovers Tuesday.
Seniors Erica Norwood and Chakecia Miller led the way for Campbell, with Norwood scoring 25 points - 20 of which came in the first half - and Miller adding 20 points and 12 steals.
"Our senior leadership really stepped up for us," McClure said.
Kendra Patrick scored 16 points for Valdosta (18-12), while LaPorchia Bridges added 12 and Sierra Foster had 10.
Campbell stormed out to an 18-8 lead in the first quarter, fueled by Norwood's 14 points and three 3-pointers, not to mention nine Valdosta turnovers.
Norwood led off the game with a 3-pointer and Angel Foster hit a jumper. Miller then scored on a layup off of a steal by Baylee Hawkins to give Campbell a 7-0 lead with 6:58 remaining in the first quarter.
A couple of Valdosta baskets were followed by a Norwood 3-pointer to make it 10-4 Campbell with 4:21 left in the first quarter. After a layup by Patrick, Norwood followed with another 3 to give the Lady Spartans a 13-6 advantage with 3:32 left.
Leading 14-8 with 2:38 left, Campbell finished the first quarter with a steal and layup by Miller, and then a steal by Raven Wildermuth leading to a layup by Norwood, to give the Lady Spartans an 18-8 lead at the end of the first quarter.
Campbell forced 10 more Valdosta turnovers and Norwood hit two more 3-pointers in the second quarter for a 32-18 halftime lead by the Lady Spartans, who maintained a double-digit lead the rest of the way.